Transcription: Suppository. A way to administer medications by absorbing the drug into a wax preparation, then inserting it into the rectum or vagina. Suppositories are used to treat local conditions such as vaginitis or hemorrhoids, and are also used when pills cannot be swallowed or kept down because of nausea, sore mouth, or narrowing of the esophagus. Anti-nausea suppositories may be used to combat this side effect of chemotherapy.